From harnessing the power of the atom to sequencing the human genome, the Department of Energy has a long history of developing cutting-edge science and technology. Supercomputing is no exception: DOE supercomputers top charts for fastest speeds and fuel incredible science and engineering breakthroughs. Supercomputing is now entering an era of rapid change, with advances in fields such as artificial intelligence (AI) reshaping what’s possible. To stay on the cutting edge, DOE is tackling fresh challenges that will inspire new thinking and drive innovation for supercomputing’s future. One such challenge? Cancer.